Bromine → alpha-Bromo-2'-methyl-4'-chloropropoxyacetophenone

HRID 1072032

반응식

HRID 1072032 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])[CH:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[Br:16]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:16][CH2:14][C:13]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])=[CH:7][C:2]=1[CH3:1])=[O:15]

참가 물질

5

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 693770792'-Methyl-4'-chloropropoxyacetophenone

생성물 1

HCID 22015662alpha-Bromo-2'-methyl-4'-chloropropoxyacetophenone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of the product of Step A (9.33 g) in ether (42 mL) was treated with bromine (2.1 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (100 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (100 mL). The combined organic layers were washed with a fresh portion of water (100 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (11 g).

후처리

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (100 mL)
  3. washThe combined organic layers were washed with a fresh portion of water (100 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-73201a22ea2b49ada47bed27a7d29afe
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06908929B2

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