Piperidine → 5-(4-chloro-2-oxo-1,2-dihydro-pyrrolo [2,3-b]pyridin-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide

HRID 1072133노트

반응식

HRID 1072133 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][C:9](=[O:11])[CH2:10][C:3]=12.[N:12]1([CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:29]=O)=[C:26]([CH3:28])[CH:27]=2)=[O:22])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.N1CCCCC1>C(O)C>[N:12]1([CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:29]=[C:10]3[C:3]4[C:4](=[N:5][CH:6]=[CH:7][C:2]=4[Cl:1])[NH:8][C:9]3=[O:11])=[C:26]([CH3:28])[CH:27]=2)=[O:22])[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 111945634-Chloro-1H-pyrrolo[2,3-B]pyridin-2(3H)-oneHCID 112770865-formyl-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide

생성물 1

HCID 701609235-(4-chloro-2-oxo-1,2-dihydro-pyrrolo [2,3-b]pyridin-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A reaction mixture of 4-chloro-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one (85 mg, 0.5 mmol), 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide (125 mg, 0.5 mmol), 0.1 mL of piperidine and 10 mL of ethanol was stirred at room temperature overnight. The yellow precipitate was filtered after cooled with an ice bath, washed with cold ethanol and dried to give 185 mg (92%) of 5-(4-chloro-2-oxo-1,2-dihydro-pyrrolo[2,3-b]pyridin-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide.

후처리

  1. filtrationThe yellow precipitate was filtered
  2. temperatureafter cooled with an ice bath
  3. washwashed with cold ethanol
  4. customdried

출처 및 근거

ORD 기록
ord-40a65e0ad2ba47c4845aca3e38e75981
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06908930B2

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