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Piperidine → 5-(6-Oxo-4-piperidin-1-YL-6,7-dihydro-pyrrolo[2,3-D]pyrimidin-5-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (2-morpholin-4-YL-ethyl)-amide

HRID 1072137
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반응식

HRID 1072137 반응식
Cl[C:2]1[C:3]2[CH2:10][C:9](=[O:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[N:12]1([CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:28]=O)=[CH:26][CH:27]=2)=[O:22])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[NH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>C(O)C>[N:12]1([CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:28]=[C:10]3[C:3]4[C:2]([N:30]5[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]5)=[N:7][CH:6]=[N:5][C:4]=4[NH:8][C:9]3=[O:11])=[CH:26][CH:27]=2)=[O:22])[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1
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참가 물질

5

반응물 3

HCID 8082PiperidineHCID 120958704-chloro-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-oneHCID 120958715-formyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide

생성물 1

HCID 865914095-(6-Oxo-4-piperidin-1-YL-6,7-dihydro-pyrrolo[2,3-D]pyrimidin-5-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (2-morpholin-4-YL-ethyl)-amide수율 50.6%

시약·촉매·용매 1

HCID 702
Ethanol
용매

실험 절차

To a mixture of 4-chloro-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (85 mg, 0.5 mmol) and 5-formyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide (125 mg, 0.5 mmol) in ethanol (4 mL) was added 0.2 mL of piperidine. The mixture was stirred at room temperature for 20 hours. The yellow precipitate was filtered after cooled with an ice bath, washed with cold ethanol and dried to give 114 mg (50.6%) of the title compound. 1H NMR (300 MHz, DMSO-d6) δ 13.23 (br s, 1H, NH), 11.68 (br s, 1H, NH), 8.39 (m, 1H, CONHCH2), 8.32 (s, 1H, H-vinyl), 7.11 (s, 1H), 6.91-6.98 (m, 2H), 3.56 (m, 4H, 2×CH2), 3.38 (m, 6H, 3×CH), 2.39-2.47 (m, 6H, 3×CH2), 1.65 (m, 6H, 3×CH2). MS 452.2 [M++1].

후처리

  1. filtrationThe yellow precipitate was filtered
  2. temperatureafter cooled with an ice bath
  3. washwashed with cold ethanol
  4. customdried

출처 및 근거

ORD 기록
ord-ae5e2dea50574d0ebbee8bf22ff330ad
출처 데이터셋
uspto-grants-2005_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06908930B2

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