Trimethyl orthoacetate → 5-Bromo-2-methyl-1,3-benzoxazole

반응식

[NH2:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[OH:9].[C:10](OC)(OC)(OC)[CH3:11]>>[CH3:10][C:11]1[O:9][C:3]2[CH:4]=[CH:5][C:6]([Br:8])=[CH:7][C:2]=2[N:1]=1

참가 물질

반응물 2

HCID 15050Trimethyl orthoacetate

HCID 3518402-Amino-4-Bromophenol

생성물 1

HCID 101045995-Bromo-2-methyl-1,3-benzoxazole

실험 절차

A solution of 2-amino-4-bromophenol (1 g, 5.32 mmol) in trimethyl orthoacetate (20 mL) was refluxed for 1.5 hours. The reaction was then cooled and the solvent removed under reduced pressure to give 1.1 g of title compound.

후처리

temperatureThe reaction was then cooled
customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록: ord-900f703f86434b4394847e71afa5172c
출처 데이터셋: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06908935B2

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