홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Tributyltin Chloride → 7-(5-Methylthiopyridin-3-yl)carbonyl-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole

HRID 1072336
노트
인쇄 미리보기

반응식

HRID 1072336 반응식
[CH3:1][S:2][C:3]1[CH:4]=[C:5]([CH:9]([OH:18])[C:10]2[N:11]=[CH:12][N:13]3[CH:17]=[CH:16][S:15][C:14]=23)[CH:6]=[N:7][CH:8]=1.[CH2:19]([Sn:23](Cl)([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:24][CH2:25][CH2:26][CH3:27])[CH2:20][CH2:21][CH3:22].C[Si]([N-][Si](C)(C)C)(C)C.[Li+].C1COCC1>[O-2].[O-2].[Mn+4]>[CH3:1][S:2][C:3]1[CH:4]=[C:5]([C:9]([C:10]2[N:11]=[CH:12][N:13]3[CH:17]=[C:16]([Sn:23]([CH2:24][CH2:25][CH2:26][CH3:27])([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:19][CH2:20][CH2:21][CH3:22])[S:15][C:14]=23)=[O:18])[CH:6]=[N:7][CH:8]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 15096Tributyltin ChlorideHCID 223903167-[(5-Methylthiopyridin-3-yl)hydroxymethyl]imidazo[5,1-b]thiazoleHCID 23714775LiHMDS tetrahydrofuran

생성물 1

HCID 223902287-(5-Methylthiopyridin-3-yl)carbonyl-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole

시약·촉매·용매 1

HCID 178418406HCID 178418406, 화합물촉매

실험 절차

A ketone compound (408 mg) was prepared in substantially the same manner as in step b) of Synthesis Example 1, except that 430 mg of 7-[(5-methylthiopyridin-3-yl)hydroxymethyl]imidazo[5,1-b]thiazole and 320 mg of manganese dioxide were used as the starting compounds. 7-(5-Methylthiopyridin-3-yl)carbonyl-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole (179 mg) was prepared in substantially the same manner as in step c) of Synthesis Example 1, except that 138 mg of the ketone compound, 0.300 ml of tri-n-butylstannyl chloride, and 2.25 ml of a 1.0 N lithium bis(trimethylsilyl)amide/THF solution were used as the starting materials.

후처리

  1. customof Synthesis Example 1
  2. customof Synthesis Example 1

출처 및 근거

ORD 기록
ord-2e85e86ecbf74aeaa0ac531a0ef3bec2
출처 데이터셋
uspto-grants-2005_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06908913B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트