Tributyltin Chloride → HCID 22390348, 화합물

HRID 1072343노트

반응식

[S:1]1[C:5]([C:6]([C:8]2[N:9]=[CH:10][N:11]3[CH:15]=[CH:14][S:13][C:12]=23)=[O:7])=[CH:4][N:3]=[CH:2]1.[CH2:16]([Sn:20](Cl)([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:21][CH2:22][CH2:23][CH3:24])[CH2:17][CH2:18][CH3:19].C[Si]([N-][Si](C)(C)C)(C)C.[Li+].C1COCC1>>[S:1]1[C:5]([C:6]([C:8]2[N:9]=[CH:10][N:11]3[CH:15]=[C:14]([Sn:20]([CH2:21][CH2:22][CH2:23][CH3:24])([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:16][CH2:17][CH2:18][CH3:19])[S:13][C:12]=23)=[O:7])=[CH:4][N:3]=[CH:2]1

참가 물질

반응물 3

HCID 15096Tributyltin Chloride

HCID 223903387-(Thiazol-5-yl)carbonylimidazo[5,1-b]thiazole

HCID 23714775LiHMDS tetrahydrofuran

생성물 1

HCID 22390348HCID 22390348, 화합물

실험 절차

The title compound (260 mg) was prepared in substantially the same manner as in step c) of Synthesis Example 1, except that 187 mg of 7-(thiazol-5-yl)carbonylimidazo[5,1-b]thiazole, 0.235 ml of tri-n-butylstannyl chloride, and 1.2 ml of a 1.0 N lithium bis(trimethylsilyl)amide/THF solution were used as the starting materials.

후처리

customof Synthesis Example 1

출처 및 근거

ORD 기록: ord-a4116e6c60714eb7822a3dfd8f760cb7
출처 데이터셋: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06908913B2

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