Methyl triflate → 4-Nitrobenzyl (1s,5r,6s)-6-((1r)-1-hydroxyethyl)-1-methyl-2-[7-(1-methylpyridinium-3-yl)carbonylimidazo-[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate trifluoromethanesulfonate

HRID 1072357노트

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HRID 1072357 반응식
[OH:1][C@@H:2]([C@H:4]1[C:40](=[O:41])[N:6]2[C:7]([C:27]([O:29][CH2:30][C:31]3[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=3)=[O:28])=[C:8]([C:11]3[S:15][C:14]4=[C:16]([C:19]([C:21]5[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=5)=[O:20])[N:17]=[CH:18][N:13]4[CH:12]=3)[C@H:9]([CH3:10])[C@H:5]12)[CH3:3].[F:42][C:43]([F:50])([F:49])[S:44]([O:47]C)(=[O:46])=[O:45]>ClCCl>[F:42][C:43]([F:50])([F:49])[S:44]([O-:47])(=[O:46])=[O:45].[OH:1][C@@H:2]([C@H:4]1[C:40](=[O:41])[N:6]2[C:7]([C:27]([O:29][CH2:30][C:31]3[CH:32]=[CH:33][C:34]([N+:37]([O-:39])=[O:38])=[CH:35][CH:36]=3)=[O:28])=[C:8]([C:11]3[S:15][C:14]4=[C:16]([C:19]([C:21]5[CH:22]=[N+:23]([CH3:43])[CH:24]=[CH:25][CH:26]=5)=[O:20])[N:17]=[CH:18][N:13]4[CH:12]=3)[C@H:9]([CH3:10])[C@H:5]12)[CH3:3]

참가 물질

4

반응물 2

HCID 9526Methyl triflateHCID 68934911(4-nitrobenzyl) (1S,5R,6S)-6-[(1R)-1-hydroxyethyl]-2-[7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-methylcarbapen-2-em-3-carboxylate

생성물 1

HCID 1317250094-Nitrobenzyl (1s,5r,6s)-6-((1r)-1-hydroxyethyl)-1-methyl-2-[7-(1-methylpyridinium-3-yl)carbonylimidazo-[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate trifluoromethanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate (240 mg) was suspended in 10 ml of dichloromethane to prepare a suspension. Methyl trifluoromethanesulfonate (0.047 ml) was added to the suspension, and the mixture was stirred at room temperature for 20 min. The reaction solution was concentrated under the reduced pressure to give 333 mg of 4-nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(1-methylpyridinium-3-yl)carbonylimidazo-[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate trifluoromethanesulfonate.

후처리

  1. customto prepare a suspension
  2. concentrationThe reaction solution was concentrated under the reduced pressure

출처 및 근거

ORD 기록
ord-ef5f4bdd8ff34bafb7f8ea6f6553875d
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06908913B2

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