Phenacyl bromide → 2-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone

HRID 1072511노트

반응식

HRID 1072511 반응식
[CH:1]1([NH:4][CH2:5][C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=2[Cl:13])[CH2:3][CH2:2]1.Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].C(N(CC)CC)C.BrC1C=CC(C2C3C(=C(Cl)C=C(Cl)C=3)CN(C)C2)=CC=1>O1CCOCC1>[CH:1]1([N:4]([CH2:5][C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=2[Cl:13])[CH2:15][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:17])[CH2:2][CH2:3]1

참가 물질

6

반응물 4

HCID 6259Phenacyl bromideHCID 8471TriethylamineHCID 4720306Cyclopropyl-(2,4-dichloro-benzyl)-amineHCID 101772114-(4-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 223868872-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Intermediate 1 was reacted with alpha-bromoacetophenone in the presence of triethylamine in dioxane by the method described in example 1, intermediate 3. For workup, the solvent was distilled off, and the residue was taken up in ethyl acetate. It was washed twice with H2O and twice with 2 N HCl, dried with MgSO4 and concentrated. The crude product obtained in this way was reacted further without further purification.

후처리

  1. distillationFor workup, the solvent was distilled off
  2. washIt was washed twice with H2O and twice with 2 N HCl
  3. dry with materialdried with MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8cd95def416c4b37bc619ce3bc04b26b
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911453B2

반응 노트

불러오는 중…