Triethylamine → 3-(4-Pentylphenyl)propyl mesylate

HRID 1072714노트

반응식

HRID 1072714 반응식
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH2:14][OH:15])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].C(N(CC)CC)C.[S:23](Cl)([CH3:26])(=[O:25])=[O:24]>C1COCC1>[S:23]([O:15][CH2:14][CH2:13][CH2:12][C:9]1[CH:8]=[CH:7][C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:11][CH:10]=1)(=[O:25])(=[O:24])[CH3:26]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 223875953-(4-Pentylphenyl)propanol

생성물 1

HCID 223874783-(4-Pentylphenyl)propyl mesylate수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-(4-pentylphenyl)propanol (30.8 g, 149 mmol) and triethylamine (22 ml, 155 mmol) in THF (300 ml) was added mesyl chloride (11.6 ml, 150 mmol) at 0° C., and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was poured into ice and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over magnesium sulfate anhydride, and the organic layer was concentrated to give the object compound as an oily substance. 42.4 g, (yield 100%)

후처리

  1. additionThe reaction mixture was poured into ice
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over magnesium sulfate anhydride
  5. concentrationthe organic layer was concentrated
  6. customto give the object compound as an oily substance

출처 및 근거

ORD 기록
ord-c5e90e2b0fab4f7fba9bccd76f5f860d
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911468B2

반응 노트

불러오는 중…