Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → (4S,5R)-N-Carbobenzyloxy-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid methyl ester

HRID 1072943노트

반응식

HRID 1072943 반응식
[CH3:1][O:2][C:3](=[O:24])[CH:4]([OH:23])[CH:5]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8].COC(=O)[C@H](O)[C@H](C1C=CC=CC=1)NC(OCC1C=CC=CC=1)=O.CO[CH:51](OC)[C:52]1[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[CH:54][C:53]=1[O:60][CH3:61].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>C1COCC1>[CH3:1][O:2][C:3]([C@@H:4]1[O:23][CH:51]([C:52]2[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[CH:54][C:53]=2[O:60][CH3:61])[N:6]([C:7]([O:9][CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:8])[C@H:5]1[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:24]

참가 물질

6

반응물 4

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 142873251-(Dimethoxymethyl)-2,4-dimethoxybenzeneHCID 22389496N-Carbobenzyloxy-beta-phenyl isoserine methyl esterHCID 22865499(2R,3S)-N-carbobenzyloxy-beta-phenyl isoserine methyl ester

생성물 1

HCID 57035355(4S,5R)-N-Carbobenzyloxy-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

N-Carbobenzyloxy-β-phenyl isoserine methyl ester (Preparation No. 19, 3C, 0.375 g, 1.14 mM) is dissolved in dry THF (10 mL) and the solution treated with 2,4-dimethoxy benzaldehyde dimethyl acetal (4, 0.300 g, 1.42 mM) and pyridinium p-toluenesulfonate (10 mg) and the solution heated to distill off the THF and methanol. After ½ the THF is distilled off, THF (10 mL) is added and the reaction distilled to ½ volume again. The process is repeated three times. The reaction is then concentrated in vacuo and the residue chromatographed over 75 g silica gel packed and eluted in acetone-hexane (300 mL of 20-80 and 300 mL of 25-75). Fractions of 20 mL are collected and analyzed by TLC. The following fractions are combined and evaporated under vacuum.

후처리

  1. temperaturethe solution heated
  2. distillationto distill off the THF and methanol
  3. distillationis distilled off
  4. additionTHF (10 mL) is added
  5. distillationthe reaction distilled
  6. concentrationThe reaction is then concentrated in vacuo
  7. customthe residue chromatographed over 75 g silica gel
  8. washeluted in acetone-hexane (300 mL of 20-80 and 300 mL of 25-75)
  9. customFractions of 20 mL are collected
  10. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-f7b7d1a0e4cd4bbc9fab5868e6e61bbe
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911549B1

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