Sodium Chloride → 8-(1-Piperidinyl)-5,6,7,8-tetrahydroquinoline

HRID 1073147노트

반응식

HRID 1073147 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.Cl[CH:9]1[C:18]2[N:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH2:12][CH2:11][CH2:10]1.[Cl-].[Na+]>O>[N:1]1([CH:9]2[C:18]3[N:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH2:12][CH2:11][CH2:10]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 8082PiperidineHCID 137121818-Chloro-5,6,7,8-tetrahydroquinoline hydrochloride

생성물 1

HCID 200734668-(1-Piperidinyl)-5,6,7,8-tetrahydroquinoline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

3.9 ml of piperidine were introduced into a solution of 2 g of 8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride in 5 ml of water and the mixture was stirred for 15 minutes, heated for two-and-a-half hours at 57°±2° C., then cooled to ambient temperature. The medium was saturated with sodium chloride and extracted with ether. The solvent was eliminated under reduced pressure to obtain 2.07 g of 8-(1-piperidinyl)-5,6,7,8-tetrahydroquinoline.

후처리

  1. temperatureheated for two-and-a-half hours at 57°±2° C.
  2. extractionextracted with ether

출처 및 근거

ORD 기록
ord-676a1fee45c245ef88b9b154d46f3686
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968700

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