Water → HCID 54249443, 화합물

HRID 1073238

반응식

HRID 1073238 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH:24]1([CH:30]=[CH:31][C:32](Cl)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1.O>C(#N)C>[CH:24]1([CH:30]=[CH:31][C:32]([NH:17][CH2:16][CH2:15][C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:10]=2)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 2074152-(3-(Benzyloxy)phenyl)ethanamineHCID 566232073-Cyclohexylprop-2-enoyl chloride

생성물 1

HCID 54249443HCID 54249443, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

To a solution of 2-[3-benzyloxyphenyl]ethylamine (2.3 g) (prepared in a manner analogous to that described in Example 1E) in acetonitrile (25 cm3) was added powdered potassium carbonate (2.1 g) followed by 3-cyclohexylpropenoyl chloride (1.72 g) in acetonitrile (10 cm3) which was added over ten minutes. The resulting mixture was stirred for one hour and was then treated with water (40 cm3) and SVM (3 cm3) thereby causing the precipitation of an oil which solidified to give a pale tan solid after several minutes. This solid was filtered off, washed with 5% SVM in water and sucked dry. Yield=3.08 g m.p. 98°-100° C.

후처리

  1. additionwas added over ten minutes
  2. customthe precipitation of an oil which
  3. customto give a pale tan solid after several minutes
  4. filtrationThis solid was filtered off
  5. washwashed with 5% SVM in water
  6. customsucked dry

출처 및 근거

ORD 기록
ord-6ed3d95875fb434c90d2e9397a9d6a26
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968698

연결된 노트

불러오는 중…