Triethylamine → N-(2-Chlorocinnamoyl)-3-propyloxyphenethylamine

HRID 1073240노트

반응식

HRID 1073240 반응식
[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][NH2:13])[CH:8]=[CH:9][CH:10]=1)[CH2:2][CH3:3].C(OC1C=C(CCN)C=CC=1)CCC.C(N(CC)CC)C.[Cl:35][C:36]1[CH:46]=[CH:45][CH:44]=[CH:43][C:37]=1[CH:38]=[CH:39][C:40](Cl)=[O:41]>C(#N)C.O>[Cl:35][C:36]1[CH:46]=[CH:45][CH:44]=[CH:43][C:37]=1[CH:38]=[CH:39][C:40]([NH:13][CH2:12][CH2:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([O:4][CH2:1][CH2:2][CH3:3])[CH:6]=1)=[O:41]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 2737382HCID 2737382, 화합물HCID 152056182-(3-propoxyphenyl)ethanamine(SALTDATA: HCl)HCID 22379525HCID 22379525, 화합물

생성물 1

HCID 53771533N-(2-Chlorocinnamoyl)-3-propyloxyphenethylamine

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매2회

실험 절차

To a solution of 2-(3-propyloxyphenyl)ethylamine prepared in a manner analogous to that described in Example 1E (2.69 g) in acetonitrile (40 cm3) was added triethylamine (3 cm3). A solution of 2-chlorocinnamoyl chloride (3.6 g) in acetonitrile (20 cm3) was added slowly, the reaction mixture being cooled in an ice bath. When addition was complete, the mixture was stirred at room temperature for 40 minutes, treated with water (60 cm3) and SVM (2 cm3) and stirred well. The resulting precipitate was filtered off, washed and air-dried (5.49 g) m.p. 96°-99° C.

후처리

  1. temperaturethe reaction mixture being cooled in an ice bath
  2. additionWhen addition
  3. stirringstirred well
  4. filtrationThe resulting precipitate was filtered off
  5. washwashed
  6. customair-dried (5.49 g) m.p. 96°-99° C.

출처 및 근거

ORD 기록
ord-e9e8ff2f67384f5b904db53b516dd7c5
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968698

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