Water → 3-Amino-6,8-dichloro-2-(4-chlorophenyl)-4-quinolinecarboxylic acid

HRID 1073274

반응식

HRID 1073274 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([Cl:11])[CH:10]=1)[NH:7][C:6](=[O:12])[C:5]2=O.Cl.[NH2:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)=O.[OH2:26]>>[NH2:15][C:16]1[C:17]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[N:7][C:8]2[C:4]([C:5]=1[C:6]([OH:12])=[O:26])=[CH:3][C:2]([Cl:1])=[CH:10][C:9]=2[Cl:11]

참가 물질

4

반응물 3

HCID 962WaterHCID 807715,7-Dichloro-1H-indole-2,3-dioneHCID 27982112-Amino-1-(4-chlorophenyl)ethan-1-one hydrochloride

생성물 1

HCID 150859713-Amino-6,8-dichloro-2-(4-chlorophenyl)-4-quinolinecarboxylic acid

실험 절차

A solution of 5.4 g of 5,7-dichloroisatin in water was reacted with 7.21 g of 2-amino-1-(4-chlorophenyl)ethanone hydrochloride by the procedure described in example 33, giving 5.2 g of the desired compound as a yellow solid, mp 260°-261° C.

출처 및 근거

ORD 기록
ord-d3c17c6d13534627a14b7bd5ede15e74
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968702

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