Sulfuric Acid → 5-(2-Bromophenyl)-5-oxovaleric acid

HRID 1073565노트

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HRID 1073565 반응식
[OH:1]S(O)(=O)=O.[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]#[C:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]>O>[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13](=[O:1])[CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 147984675-(2-Bromophenyl)-4-pentynoic acid

생성물 1

HCID 147984685-(2-Bromophenyl)-5-oxovaleric acid

시약·촉매·용매 1

HCID 962Water용매

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온도
0 °C

실험 절차

Into 20 cc of concentrated H2SO4 was dissolved 0.1 g (0.4 mmol) of the product of Example 1 to give a brown solution. The solution was allowed to stand at room temperature for 10 minutes. Thereafter, the solution was cooled to 0° C. in an ice bath and ice was then added to it. The solution was then diluted with water and extracted twice with ethyl acetate. The combined extracts were sequentially washed once each with water and brine and then dried (MgSO4). Removal of the solvent under reduced pressure produced a yellow oil which was used without further purification.

후처리

  1. customto give a brown solution
  2. additionice was then added to it
  3. extractionextracted twice with ethyl acetate
  4. washThe combined extracts were sequentially washed once each with water and brine
  5. dry with materialdried (MgSO4)
  6. customRemoval of the solvent under reduced pressure
  7. customproduced a yellow oil which
  8. customwas used without further purification

출처 및 근거

ORD 기록
ord-17f6c2f7fdb64bccb2cae6bc2ff459f0
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04970229

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