Potassium Hydroxide → 3-[3-(Cyclopentyloxy)-4-methoxyphenyl]acrylic acid

HRID 1073750노트

반응식

HRID 1073750 반응식
[CH:1]1([O:6][C:7]2[CH:8]=[C:9](/[CH:15]=[CH:16]/[C:17]([O:19]C)=[O:18])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[K+]>CO.O>[CH:1]1([O:6][C:7]2[CH:8]=[C:9](/[CH:15]=[CH:16]/[C:17]([OH:19])=[O:18])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 5702848methyl 3-(3-cyclopentoxy-4-methoxyphenyl)-E-propenoate

생성물 1

HCID 57121053-[3-(Cyclopentyloxy)-4-methoxyphenyl]acrylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a stirring solution of 0.8 g (2.9 mmol) of methyl 3-(3-cyclopentoxy-4-methoxyphenyl)-E-propenoate in 20 mL of methanol was added dropwise 25 mL of a 1.0 N solution of potassium hydroxide in water over a 5 minute period. The mixture precipitated immediately, but returned to a solution after a 16-hour period at which time the solution was concentrated, diluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid. The analytically pure white solid which formed was collected, washed several times with cold water, and dried in vacuo.

후처리

  1. customThe mixture precipitated immediately
  2. waitreturned to a solution after a 16-hour period at which time
  3. concentrationthe solution was concentrated
  4. additiondiluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid
  5. customThe analytically pure white solid which formed
  6. customwas collected
  7. washwashed several times with cold water
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-51e25a6d680d42169ff68d870dc0f7b1
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971959

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