Ethyl 3-hydroxy-2-methylprop-2-enoate → 2-phenylthio-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

HRID 1073780노트

반응식

HRID 1073780 반응식
[NH2:1][C:2]1[S:3][C:4]([S:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:5][N:6]=1.[OH:14][CH:15]=[C:16]([CH3:22])[C:17](OCC)=O>>[C:8]1([S:7][C:4]2[S:3][C:2]3=[N:1][CH:17]=[C:16]([CH3:22])[C:15](=[O:14])[N:6]3[N:5]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 521546Ethyl 3-hydroxy-2-methylprop-2-enoateHCID 146950682-Amino-5-phenylthio-1,3,4-thiadiazole

생성물 1

HCID 156107852-phenylthio-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one수율 58%

실험 절차

Seven point two (7.2) g of the thus obtained 2-amino-5-phenylthio-1,3,4-thiadiazole and 4.9 g of ethyl 3-hydroxy-2-methyl-2-propenoate were mixed with 13 g of polyphosphoric acid. By the same procedure as in Preparation Example 2, 5.9 g of 2-phenylthio-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained m.p. 141°~143° C. Yield 58%.

후처리

  1. customBy the same procedure as in Preparation Example 2

출처 및 근거

ORD 기록
ord-ca16d8dc518148c2b6a07b5b2cfbb901
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971971

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