6-[5-Cyano-2-hydroxy-1-(2-methylpropenyl)benzyl]pyrazine 1-oxide → 2-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrazine 1-oxide

HRID 1073956노트

반응식

HRID 1073956 반응식
[C:1]([C:3]1[CH:4]=[CH:5][CH:6]([OH:21])[C:7](C=C(C)C)([CH:16]=1)[CH2:8][C:9]1[N+:14]([O-:15])=[CH:13][CH:12]=[N:11][CH:10]=1)#[N:2]>C(OCC)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:21][C:3]([CH3:4])([CH3:16])[CH2:1][CH:8]([C:9]3[CH:10]=[N:11][CH:12]=[CH:13][N+:14]=3[O-:15])[C:7]=2[CH:16]=1)#[N:2]

참가 물질

3

반응물 1

HCID 221569356-[5-Cyano-2-hydroxy-1-(2-methylpropenyl)benzyl]pyrazine 1-oxide

생성물 1

HCID 198956162-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrazine 1-oxide수율 11.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

In an analogous manner to that described in the first paragraph of Example 8, from 0.35 g of 6-[5-cyano-2-hydroxy-1-(2-methylpropenyl)benzyl]pyrazine 1-oxide there was obtained 0.02 g of 2-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrazine 1-oxide in the form of a white solid of melting point 166°-168° C. (from diethyl ether).

출처 및 근거

ORD 기록
ord-f9929dcb390647fa8036fbc73c9afeab
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971982

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