HCID 23713292, 화합물 → 6-chloropyridine-2-sulfonic Acid

HRID 1074218

반응식

HRID 1074218 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([O-:11])(=[O:10])=[O:9])[N:3]=1.[Na+]>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([OH:11])(=[O:10])=[O:9])[N:3]=1

참가 물질

3

반응물 1

HCID 23713292HCID 23713292, 화합물

생성물 1

HCID 27628906-chloropyridine-2-sulfonic Acid수율 96.6%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Into 0.82 g (3.8 mmol) of sodium 2-chloropyridine-6-sulfonate prepared in accordance with Example 1, 10 ml of concentrated hydrochloric acid was added, and the mixture was stirred at room temperature overnight. Then, the solvent was distilled off, and after an addition of 200 ml of 2-propanol, the residue was heated. Insoluble matters were removed by filtration, and the filtrate was distilled under reduced pressure to obtain 710 mg (96.6%) of 2-chloropyridine-6-sulfonic acid as crystalline solid. Purification was conducted by recrystallization from 2-propanol.

후처리

  1. additionwas added
  2. distillationThen, the solvent was distilled off
  3. additionafter an addition of 200 ml of 2-propanol
  4. temperaturethe residue was heated
  5. customInsoluble matters were removed by filtration
  6. distillationthe filtrate was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-aa9c7b4c6d564749855d4a6a05427629
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04973697

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