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Water → Methyl 4'-(benzyloxy)-[1,1'-biphenyl]-4-carboxylate

HRID 1074304
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인쇄 미리보기

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HRID 1074304 반응식
FC(F)(F)[CH:3]([O:10][C:11]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)C=C(C(Cl)=O)C=C2)=O)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]C.[C:28](=O)([O-])[O-:29].[K+].[K+].[CH2:34](Br)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.[OH2:42]>CN(NC=O)C>[CH3:28][O:29][C:34]([C:35]1[CH:40]=[CH:39][C:38]([C:6]2[CH:5]=[CH:4][C:3]([O:10][CH2:11][C:13]3[CH:22]=[CH:21][CH:20]=[CH:15][CH:14]=3)=[CH:8][CH:7]=2)=[CH:37][CH:36]=1)=[O:42]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 148475736-(1-Trifluoromethylheptyloxycarbonyl)-naphathalene-2-carboxylic acid chloride

생성물 1

HCID 15084903Methyl 4'-(benzyloxy)-[1,1'-biphenyl]-4-carboxylate

시약·촉매·용매 1

HCID 304376
N',N'-Dimethylformohydrazide
용매

반응 조건

온도
110 °C

실험 절차

The product obtained in Item (1) in the amount of 4.1 g was dissolved in 100 ml of dimethylaminoformamide. The solution was added with anhydrous potassium carbonate 3.6 g and after heating upto 110° C. dropped with benzyl bromide 4.1 g during one hour to be stirred thereafter at a temperature of 140° C. for 4 hours. The reaction solution was taken into a large amount of water to precipitate crystal, which was dried to obtain the captioned product in the amount of 6.6 g.

후처리

  1. customto precipitate crystal, which
  2. customwas dried
  3. customto obtain the captioned product in the amount of 6.6 g

출처 및 근거

ORD 기록
ord-e5a603c947234c3a83f61e6dcab751dd
출처 데이터셋
uspto-grants-1990_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04973738

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