Hexane → 1-(4-Chlorophenyl)-2-cyclopropylpropan-1-one

HRID 1074318노트

반응식

HRID 1074318 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:14])[CH:9]([CH:11]2[CH2:13][CH2:12]2)[CH3:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.CCCCCC>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:14])[CH:9]([CH:11]2[CH2:13][CH2:12]2)[CH3:10])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 8471TriethylamineHCID 190783851-(4-Chlorophenyl)-2-cyclopropylpropan-1-ol

생성물 1

HCID 134886191-(4-Chlorophenyl)-2-cyclopropylpropan-1-one수율 86%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

After 15 minutes 1-(4-chlorophenyl)-2-cyclopropylpropan-1-ol (44.72 g, 212 mmol) in dry dichloromethane (330 ml) was added over approximately 35 minutes. After 75 minutes triethylamine (154 ml), 1105 mmol) was added and the mixture allowed to warm to room temperature. Hexane was added and the mixture washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate solution and water, dried and evaporated in vacuo. Chromatography [SiO2, hexane-ethyl acetate (100:0) to (90:10)] gave 1-(4-chlorophenyl)-2-cyclopropylpropan-1-one (38.0 g, 86%).

후처리

  1. washthe mixture washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate solution and water
  2. customdried
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-c83872dbc42b4e8ab42ab55217af0e02
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04973767

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