Piperidine → HCID 20496598, 화합물

HRID 1074389노트

반응식

HRID 1074389 반응식
Cl[C:2]1[CH:14]=[CH:13][C:5]2=[N:6][C:7]3[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=3[N:4]2[N:3]=1.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[CH:14]=[CH:13][C:5]3=[N:6][C:7]4[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=4[N:4]3[N:3]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

3

반응물 2

HCID 8082PiperidineHCID 11148455HCID 11148455, 화합물

생성물 1

HCID 20496598HCID 20496598, 화합물

실험 절차

A solution of 5.0 g of 2-chloro-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole in 30 ml of piperidine was stirred and heated at reflux for 72 hours. The reaction mixture was poured into 200 ml of ice water and the tan solid which formed was separated by filtration and air dried. It was then recrystallized from a mixture of ethanol and water to give 2-(1-piperidinyl)-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole melting at about 184°-185° C.

후처리

  1. temperatureheated
  2. temperatureat reflux for 72 hours
  3. customthe tan solid which formed
  4. customwas separated by filtration and air
  5. customdried
  6. customIt was then recrystallized from a mixture of ethanol and water

출처 및 근거

ORD 기록
ord-85e88e01e10f4ea59afe1e3eb82b2c5d
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04391806

반응 노트

불러오는 중…