Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1-Diphenylacetone | HCID 69907 | — |
| 반응물 | 3-Bromo-1,1-diphenylacetone | HCID 2794635 | — |
| 반응물 | 5,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol | HCID 3866487 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide | HCID 15571212 | — |
반응 단계
A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone as described in Example 22. This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 1.0 g. of tetrahydro-5,5-dimethyl-2(1H)-pyrimidinethione in 50 ml. of acetone. The mixture is allowed to stand at room temperature for 24 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 259°-261° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04393004 |
| 출처 데이터셋 | uspto-grants-1983_07 |
| ORD ID | ord-3130c19ef8eb4df6a7981fdcec590ce9 |
| 출처 메모 | uspto-grants-1983_07 |