Potassium Carbonate → 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone

HRID 1074617노트

반응식

HRID 1074617 반응식
Cl[CH2:2][CH2:3][CH2:4][N:5]1[CH:14]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:21].C(=O)([O-])[O-].[K+].[K+]>N1CCCCC1>[N:5]1([CH2:2][CH2:3][CH2:4][N:5]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]2=[O:21])[CH2:14][CH2:13][CH2:12][CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 128129652-(3-chloropropyl)-4-phenyl-1(2H)-isoquinolone

생성물 1

HCID 131747412-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone수율 180%

시약·촉매·용매 1

HCID 8082Piperidine용매

실험 절차

Then, 14.9 g of 2-(3-chloropropyl)-4-phenyl-1(2H)-isoquinolone, 7 g of anhydrous potassium carbonate and 40 ml of piperidine were mixed and heated at reflux for 5 hours. Thereafter, any excess of piperidine was distilled off and the residue was dissolved in dichloromethane. The solution was washed with water, dried and the solvent was distilled off. The resulting crystals were recrystallized from a mixture of diethyl ether and petroleum ether to obtain 15.6 g of 2-(3-piperidinopropyl)-4-phenyl-1(2H)-isoquinolone having a melting point of 117.5° C. as colorless prisms.

후처리

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. distillationThereafter, any excess of piperidine was distilled off
  4. dissolutionthe residue was dissolved in dichloromethane
  5. washThe solution was washed with water
  6. customdried
  7. distillationthe solvent was distilled off
  8. customThe resulting crystals were recrystallized from a mixture of diethyl ether and petroleum ether

출처 및 근거

ORD 기록
ord-ca40588b2ee04409a36c6936f2d90ad6
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04393210

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