Water → HCID 54046372, 화합물

HRID 1074647노트

반응식

HRID 1074647 반응식
[C:1]([C:4]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH:5]=1)(=[O:3])[CH3:2].[CH3:16][Mg]Cl.O>O1CCCC1>[CH3:2][C:1]([CH3:16])([C:4]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH:5]=1)[OH:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 1090051-(Cyclododec-1-en-1-yl)ethan-1-oneHCID 178418332HCID 178418332, 화합물

생성물 1

HCID 54046372HCID 54046372, 화합물수율 96%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

52 g (0.25 mole) of 1-acetyl-1-cyclododecene, prepared as described in Example 2, are added over 30 minutes to 200 ml of a 1.5-molar solution of methyl-magnesium chloride in tetrahydrofuran at from 0° to +10° C. After completion of the addition, the reaction mixture is hydrolyzed with 20 ml of water and the tetrahydrofuran solution is filtered to remove the salt which has precipitated. After destilling off the tetrahydrofuran under reduced pressure (50° C./20 mbars) the product which remains is fractionated. 52 g of dimethyl-cyclododecenyl-carbinol (96% yield) of boiling point=108°-112° C./0.01 mm Hg and refractive index nD25 =1.5000 are obtained.

후처리

  1. additionAfter completion of the addition
  2. filtrationthe tetrahydrofuran solution is filtered
  3. customto remove the salt which
  4. customhas precipitated
  5. customunder reduced pressure (50° C./20 mbars)

출처 및 근거

ORD 기록
ord-755ca918e2e0460e9c573fe8196f2e3d
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04393245

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