1H-1,2,4-Triazole → 1-(1-Butoxyethyl)-1H-1,2,4-triazole

HRID 1074890노트

반응식

HRID 1074890 반응식
Cl[CH:2]([O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:3].[NH:9]1[CH:13]=[N:12][CH:11]=[N:10]1>C(#N)C>[N:9]1([CH:2]([O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:3])[CH:13]=[N:12][CH:11]=[N:10]1

참가 물질

4

반응물 2

HCID 92571H-1,2,4-TriazoleHCID 12617703HCID 12617703, 화합물

생성물 1

HCID 126262961-(1-Butoxyethyl)-1H-1,2,4-triazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Crude n-butyl 1-chloroethyl ether (Straus and Weber, Ann, 1932, 498, 124) was treated with 1,2,4-triazole (2.4 g) in acetonitrile (50 ml) to give at once a precipitate. The mixture was refluxed for 2 hours. The solvent was removed under reduced pressure. The residue was treated with water and extracted with diethyl ether. The ethereal layer was washed with water and dried over magnesium sulphate, and the solvent was removed to give the title product as a colourless oil, which was shown by GLC to be 95% pure.

후처리

  1. customto give at once a precipitate
  2. temperatureThe mixture was refluxed for 2 hours
  3. customThe solvent was removed under reduced pressure
  4. additionThe residue was treated with water
  5. extractionextracted with diethyl ether
  6. washThe ethereal layer was washed with water
  7. dry with materialdried over magnesium sulphate
  8. customthe solvent was removed

출처 및 근거

ORD 기록
ord-06395c26ada94d9997f77c5a4f844b68
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04394380

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