Acetyl chloride → 1-p-Chlorophenyl-1-acetoxy-2-(1,2,4-triazol-1-yl)-ethane

HRID 1074897

반응식

HRID 1074897 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:15])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:23](Cl)(=[O:25])[CH3:24]>C(OCC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:15][C:23](=[O:25])[CH3:24])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 5580621-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

생성물 1

HCID 204952251-p-Chlorophenyl-1-acetoxy-2-(1,2,4-triazol-1-yl)-ethane

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

1-p-Chlorophenyl-2-(1,2,4-triazol-1-yl)-ethanol (2.24 g) and triethylamine (1.1 g) in dry diethyl ether (50 ml) were treated with acetyl chloride (0.8 g) in dry diethyl ether (5 ml) and the mixture was stirred for 3 hours at room temperature to give a white solid which was filtered off and washed with ether. The solvent was removed from the filtrate to give a brown oil. The oil was distilled to give the title compound as a semi-solid which could not be purified further.

후처리

  1. customto give a white solid which
  2. filtrationwas filtered off
  3. washwashed with ether
  4. customThe solvent was removed from the filtrate
  5. customto give a brown oil
  6. distillationThe oil was distilled

출처 및 근거

ORD 기록
ord-3d309a90b0e34583a4249dc890aaa831
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04394380

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