Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Piperidinecarboxamide → N-benzylpiperidine-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Piperidinecarboxamide | HCID 3772 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-benzylpiperidine-4-carboxamide | HCID 3868064 | 35% |
반응 단계
4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723490 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-aad08f27e18e4070affc2570d3f9689b |
| 출처 메모 | uspto-grants-1998_03 |