Sodium Cyanide → 3-Cyanomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin

HRID 1075019노트

반응식

HRID 1075019 반응식
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=[O:13])[CH2:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:18]=1.[C-:19]#[N:20].[Na+]>CN(C)C=O>[C:19]([CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=[O:13])[CH2:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:18]=1)#[N:20]

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 202702683-Bromomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin

생성물 1

HCID 202702303-Cyanomethyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Dissolve 6.4 gm. of the bromide of Step 2 in 75 cc. of dimethylformamide and add 2.95 gm. of sodium cyanide. Stir the mixture at room temperature for 1.5 hours. Dilute with 600 cc. of water and extract three times with ether. Wash the combined organics with water, dry and strip to a solid residue. Triturate in hexane and recover the solid by filtration.

후처리

  1. dissolutionDissolve 6.4 gm
  2. additionDilute with 600 cc
  3. extractionof water and extract three times with ether
  4. washWash the combined organics with water
  5. customdry
  6. customTriturate in hexane
  7. customrecover the solid
  8. filtrationby filtration

출처 및 근거

ORD 기록
ord-acde7dea38374252aa002e970daa77bb
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04394515

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