Water → Acifluorfen-methyl

HRID 1075317

반응식

HRID 1075317 반응식
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[CH:9]=[CH:10][C:11]([N+:18]([O-:20])=[O:19])=[C:12]([CH:17]=2)[C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1.[Cl:25]Cl.O>CCOCC>[Cl:25][C:5]1[CH:4]=[C:3]([C:2]([F:23])([F:24])[F:1])[CH:22]=[CH:21][C:6]=1[O:7][C:8]1[CH:9]=[CH:10][C:11]([N+:18]([O-:20])=[O:19])=[C:12]([CH:17]=1)[C:13]([O:15][CH3:16])=[O:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 24526ChlorineHCID 13209694Methyl 2-nitro-5-[4-(trifluoromethyl)phenoxy]benzoate

생성물 1

HCID 91642Acifluorfen-methyl

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Methyl 5-(4-trifluoromethylphenoxy)-2-nitrobenzoate is stirred with a catalytic amount of ferric chloride. The reaction mixture was heated to 70° C. under a continuous stream of chlorine gas. After 2.5 hours, the mixture was taken up in ether, shaken with water and the organic phase was dried over MgSO4. The ether was evaporated to afford methyl 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoate. NMR (CDCl3)δ8.2-7 (m,6) 4.0 (2,3). TLC (40% ether/hexane) Rf ≈.4.

후처리

  1. dry with materialthe organic phase was dried over MgSO4
  2. customThe ether was evaporated

출처 및 근거

ORD 기록
ord-c85e0659d8554c0b9334c310b60f0b5a
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04395570

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