1-Methyl-4-piperidone → 5-Methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrrolo[3,2-b]pyridine

반응식

[CH3:1][O:2][C:3]1[N:8]=[C:7]2[CH:9]=[CH:10][NH:11][C:6]2=[CH:5][CH:4]=1.[CH3:12][N:13]1[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]1>>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:16]3[CH2:17][CH2:18][N:13]([CH3:12])[CH2:14][CH:15]=3)=[CH:10][NH:11][C:6]2=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 740491-Methyl-4-piperidone

HCID 53243695-methoxy-1H-pyrrolo[3,2-b]pyridine

생성물 1

HCID 110101635-Methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrrolo[3,2-b]pyridine수율 84%

실험 절차

Beginning with 0.80 gm (5.4 mMol) of 5-methoxypyrrolo-[3,2-b]pyridine and 1.2 mL (10.1 mMol) 1-methyl-4-piperidone, 1.1 gm (84%) of the title compound were recovered as a yellow solid essentially by the procedure described in Example 5. An analytical sample was recrystallized from methanol.

출처 및 근거

ORD 기록: ord-b4ed7dcdb7724f2985fc341b9c4689b3
출처 데이터셋: uspto-grants-1999_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05905084

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