참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Bromoacetyl bromide | HCID 61147 | — |
| 반응물 | Methyl 3-thiophenecarboxylate | HCID 574151 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-(2-Bromo-acetyl)-thiophene-3-carboxylic acid methyl ester | HCID 53904546 | — |
반응 단계
A solution of bromoacetyl bromide (13.52 g, 0.067 mol) in 20 ml of CH2Cl2 was added dropwise to a solution of aluminum chloride (13.4 g, 0.105 mol) in 50 ml of CH2Cl2 at 0° C. The mixture was stirred for 1 h at 0° C., and then a solution of methyl 3-thiophenecarboxylate (9.49 g, 0.067 mol) in CH2Cl2 (50 ml) was added dropwise. The stirring was continued for 12 h and then the mixture was poured over water and ice and extracted with CH2Cl2. The organic phase was washed twice with water, dried over magnesium sulfate and concentrated in a rotary evaporator under vacuum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05905088 |
|---|
| 출처 데이터셋 | uspto-grants-1999_05 |
|---|
| ORD ID | ord-c2d61c34bc884e68af637b7e5e87e5f4 |
|---|
| 출처 메모 | uspto-grants-1999_05 |
|---|
