Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl 5-[(3-iodo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)-acetyl]-3-thiophenecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Iodo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 10711463 | — |
| 반응물 | 5-(2-Bromo-acetyl)-thiophene-3-carboxylic acid methyl ester | HCID 53904546 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | Methyl 5-[(3-iodo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yloxy)-acetyl]-3-thiophenecarboxylate | HCID 67581914 | — |
반응 단계
A solution of 3-iodo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol (4 g, 12.1 mmol), methyl 5-bromoacetyl-3-thiophenecarboxylate (3.18 g, 12.1 mmol) and potassium carbonate (1.84 g, 13.3 mmol) in methyl ethyl ketone (100 ml), was heated under reflux for 4 h. The reaction medium was filtered and then concentrated in a rotary evaporator. The mixture was extracted with ethyl ether. The organic phase was washed with water, dried over magnesium sulfate and concentrated in a rotary evaporator under vacuum at 40° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05905088 |
| 출처 데이터셋 | uspto-grants-1999_05 |
| ORD ID | ord-f15a7a82bcb745ee9e03b7f2f77866b9 |
| 출처 메모 | uspto-grants-1999_05 |