Propionamidine hydrochloride → HCID 21541178, 화합물

HRID 1075781

반응식

HRID 1075781 반응식
[C:1]([NH2:5])(=[NH:4])[CH2:2][CH3:3].CO[CH:8]=[C:9]([CH2:12][NH:13][CH:14]=[O:15])[C:10]#[N:11]>C(O)C>[CH2:2]([C:1]1[N:5]=[C:10]([NH2:11])[C:9]([CH2:12][NH:13][CH:14]=[O:15])=[CH:8][N:4]=1)[CH3:3]

참가 물질

4

반응물 2

HCID 415117Propionamidine hydrochlorideHCID 54062148alpha-Methoxymethylene-beta-formylaminopropionitrile

생성물 1

HCID 21541178HCID 21541178, 화합물수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매3회

반응 조건

온도
25 °C

실험 절차

In 50 parts by volume of ethanol is dissolved 14 parts of α-methoxymethylene-β-formylaminopropionitrile. To the solution is added 100 parts by volume of an ethanol solution containing 17 parts of propioamidine. The mixture is reacted at 30°C for 0.5 hour. After the reaction, ethanol is distilled off and the residue is cooled at 25°C, whereby 18 parts of 2-ethyl-4-amino-5-formylaminomethylpyrimidine is obtained as crystals. (Yield: 100 %). Recrystallization of the crystals from benzene-ethanol mixture gives colorless crystals melting at 185°C.

후처리

  1. customThe mixture is reacted at 30°C for 0.5 hour
  2. distillationis distilled off

출처 및 근거

ORD 기록
ord-a84e57b730254675a6ed4814c194a5b9
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954756

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