Sulfuric Acid → N-methyl-2H-3-isoquinolone

반응식

[CH:1]([N:3]([CH3:13])[C:4](=[O:12])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.S(=O)(=O)(O)O.S(O)(O)(=O)=O.CN1C(=O)C=C2C(C=CC=C2)=C1>C(O)C>[CH3:1][N:3]1[C:4](=[O:12])[CH:5]=[C:6]2[C:11]([CH:10]=[CH:9][CH:8]=[CH:7]2)=[CH:13]1

참가 물질

실험 절차

A solution of 80 g. N-formyl-N-methyl-2-phenyl-acetamide in 200 ml. concentrated sulfuric acid is left to stand for 12 hours at ambient temperature in an atmosphere of nitrogen. This solution is then poured, while stirring, into 1 liter ethanol and cooled in an ice bath in order to maintain the temperature at about 20°-30°C. The crystalline product obtained is filtered off and washed with cold ethanol and dried. There are obtained 70 g. N-methyl-2H-3-isoquinolone sulfate, which has a melting point of 235°-236°C.; yield 60% of theory. The analysis shows that it is a compound of the empirical formula C10H9NO.H2SO4 :