Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanoacetamide → Piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanoacetamide | HCID 7898 | — |
| 반응물 | Ethyl formate | HCID 8025 | — |
| 반응물 | 4-Dimethylaminoacetophenone | HCID 75037 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 4-(Dimethylamino)-beta-oxobenzenepropanal | HCID 12654798 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Piperidine | HCID 8082 | — |
| 생성물 | 6-[p-(Dimethylamino)phenyl]-1,2-dihydro-2-oxonicotinonitrile | HCID 21404559 | — |
반응 단계
From a solution of the sodium salt of p-(dimethylamino)benzoylacetaldehyde in 400 ml. of water (prepared from 11.4 g. of sodium methoxide in 100 ml. of tetrahydrofuran, and a solution of 29.3 g. of p-(dimethylamino)acetophenone [J.A.C.S. 73, 864 (1951)]and 13.3 g. of ethyl formate in 130 ml. of tetrahydrofuran), 18.5 g. of 2-cyanoacetamide and a solution consisting of 2.3 ml. of acetic acid, 5.2 ml. of water and 4.0 ml. of piperidine, there is obtained 6-[p-(dimethylamino)phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 280°-292° (dec.) after crystallization from aqueous dimethyl sulfoxide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03954734 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-60e8c696dc5f4421b33eb14ab0483060 |
| 출처 메모 | uspto-grants-1976_05 |