Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanoacetamide → Piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanoacetamide | HCID 7898 | — |
| 반응물 | Ethyl formate | HCID 8025 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | p-(4-Propyl-1-piperazinyl)acetophenone | HCID 21404502 | — |
| 반응물 | p-(4-Propyl-1-piperazinyl)benzoylacetaldehyde | HCID 54256791 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Piperidine | HCID 8082 | — |
| 생성물 | 3-Cyano-2-pyridone | HCID 577543 | — |
반응 단계
From a solution of the sodium salt of p-(4-propyl-1-piperazinyl)benzoylacetaldehyde in 150 ml. of water (prepared from 5.7 g. of sodium methoxide in 500 ml. of tetrahydrofuran, and a solution of 24.6 g. of p-(4-propyl-1-piperazinyl)acetophenone and 8.0 ml. of ethyl formate in 100 ml. of tetrahydrofuran), 8.4 g of 2-cyanoacetamide and a solution consisting of 0.95 ml. of acetic acid, 4.0 ml. of water and 0.9 ml. of piperidine, there is obtained 6-[p-propyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 288°-290° (dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03954734 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-c374f6d440074cc4b6a9415448a92f57 |
| 출처 메모 | uspto-grants-1976_05 |