Pyridine → N-cyclopropanecarbonyl-5-bromovaleramide

HRID 1075842

반응식

HRID 1075842 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](Cl)=[O:7].[CH:9]1([C:12]([NH2:14])=[O:13])[CH2:11][CH2:10]1.N1C=CC=CC=1>COCCOC>[CH:9]1([C:12]([NH:14][C:6](=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2][Br:1])=[O:13])[CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 80376CyclopropanecarboxamideHCID 5211735-Bromovaleryl chloride

생성물 1

HCID 21540959N-cyclopropanecarbonyl-5-bromovaleramide수율 40%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

A solution of 7.96 g. of 5-bromovaleric acid chloride, 3.40 g. of cyclopropanecarboxamide, 3.16 g. of pyridine, and 20 ml. of 1,2-dimethoxyethane was heated to reflux under nitrogen for 1.5 hours, then was concentrated by rotary evaporation. The resultant semi-solid was triturated with methylene chloride (2X). The combined methylene chloride layers were washed with saturated brine, were dried (anhydrous magnesium sulfate), were treated with activated charcoal, and were filtered. The filtrate was concentrated on a steam-bath with addition of hexane until crystallization started. Thus, 3.98 g. (40% yield) of white, crystalline N-cyclopropanecarbonyl-5-bromovaleramide was obtained melting at 114°-115°C.

후처리

  1. temperatureto reflux under nitrogen for 1.5 hours
  2. concentrationwas concentrated by rotary evaporation
  3. customThe resultant semi-solid was triturated with methylene chloride (2X)
  4. washThe combined methylene chloride layers were washed with saturated brine
  5. dry with materialwere dried (anhydrous magnesium sulfate)
  6. additionwere treated with activated charcoal
  7. filtrationwere filtered
  8. concentrationThe filtrate was concentrated on a steam-bath with addition of hexane until crystallization

출처 및 근거

ORD 기록
ord-3223fb83941c4d6d8d19abeb00875317
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954741

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