Methanesulfonamide → 5-Bromo-N-methanesulfonylpentanamide

HRID 1075845

반응식

HRID 1075845 반응식
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12]>C(OCC)(=O)C>[CH3:1][S:2]([NH:5][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][Br:6])(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 72879MethanesulfonamideHCID 5211735-Bromovaleryl chloride

생성물 1

HCID 202961415-Bromo-N-methanesulfonylpentanamide수율 74.8%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 23.5 g. (0.25 mole) of methanesulfonamide and 49.8 g. (0.25 mole) of 5-bromovaleric acid chloride was heated at 80-85° (oil bath) for 45 minutes. The brown reaction mixture was allowed to cool and was dissolved in ethyl acetate. The organic solution was washed with water and saturated brine, was dried (anhydrous magnesium sulfate), was Darcoed, concentrated, and cooled to afford the white, crystalline N-methanesulfonyl-5-bromovaleramide weighing 48.2 g. (74.8% yield) which melted at 97°-98°.

후처리

  1. additionA mixture of 23.5 g
  2. temperatureto cool
  3. washThe organic solution was washed with water and saturated brine
  4. dry with materialwas dried (anhydrous magnesium sulfate)
  5. concentrationconcentrated
  6. temperaturecooled

출처 및 근거

ORD 기록
ord-0eff3f6cdbf943e0a306fa9c72ffb88a
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954741

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