N-methylhydroxylamine hydrochloride → alpha-(1-Methyl-2-nitroimidazole-5-yl)-N-methylnitrone

HRID 1075956

반응식

HRID 1075956 반응식
[CH3:1][N:2]1[C:6]([CH:7]=O)=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10].Cl.[CH3:13][NH:14][OH:15].C(=O)(O)[O-].[Na+]>C(O)C>[CH3:1][N:2]1[C:6]([CH:7]=[N+:14]([CH3:13])[O-:15])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10]

참가 물질

5

반응물 3

HCID 77906N-methylhydroxylamine hydrochlorideHCID 1003901-Methyl-2-nitro-1H-imidazole-5-carboxaldehydeHCID 516892Sodium Bicarbonate

생성물 1

HCID 325650alpha-(1-Methyl-2-nitroimidazole-5-yl)-N-methylnitrone

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 0.250 g. of 1-methyl-2-nitro-5-imidazolecarboxaldehyde, 0.150 g. of N-methylhydroxylamine hydrochloride and 0.150 g. of sodium bicarbonate is refluxed in 80 ml. of anhydrous ethanol for 2 hours and after filtration is concentrated to small volume. The title compound crystallizes on cooling. Yield: 0.24 g. m.p. 208° -209° C.

후처리

  1. additionA mixture of 0.250 g
  2. filtrationafter filtration
  3. concentrationis concentrated to small volume
  4. customThe title compound crystallizes
  5. temperatureon cooling

출처 및 근거

ORD 기록
ord-4b173e1c42574c94b393574ccd70786e
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954789

연결된 노트

불러오는 중…