1-Methyl-2-nitro-1H-imidazole-5-methanol → 1-Methyl-2-nitro-1H-imidazole-5-carboxaldehyde

HRID 1075969노트

반응식

HRID 1075969 반응식
[CH3:1][N:2]1[C:6]([CH2:7][OH:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10]>O=[Mn]=O.C1C=CC=CC=1>[CH3:1][N:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10]

참가 물질

4

반응물 1

HCID 702921-Methyl-2-nitro-1H-imidazole-5-methanol

생성물 1

HCID 1003901-Methyl-2-nitro-1H-imidazole-5-carboxaldehyde수율 40.5%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 241Benzene용매

실험 절차

To a solution of 0.15 g. of 1-methyl-2-nitro-5-hydroxymethylimidazole in 20 ml. of benzene, 0.33 g. of MnO2 is added and the reaction mixture is heated on the steambath for 2 hours. After filtration and evaporation to dryness under vacuum, the crude product is crystallized from ethyl acetate and 0.060 g. (40.5%) of 1-methyl-2-nitro-5-imidazolaldehyde is obtained.

후처리

  1. temperaturethe reaction mixture is heated on the steambath for 2 hours
  2. filtrationAfter filtration and evaporation to dryness under vacuum
  3. customthe crude product is crystallized from ethyl acetate and 0.060 g

출처 및 근거

ORD 기록
ord-46bcf94c66ce401ebe1aefe460d1fb12
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954789

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