Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Benzyl piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Piperidin-4-ol | HCID 79341 | — |
| 반응물 | Chloroform methanol | HCID 21584188 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzyl piperidine-1-carboxylate | HCID 228749 | 59.2% |
반응 단계
4-Hydroxypiperidine (10.8 g, 107 mmol) and Et3N (17 mL, 123 mmol) in 80 mL of CH2Cl2 was cooled in an ice bath whereupon benzyl chloroformate (16.3 mL, 114 mmol) was added. After stirring 1.5 h at R.T. the mixture was subjected to standard work-up conditions to give 13.9 g (55%) of N-Cbz-piperidine after chromatography (CHCl3 /MeOH; 10:1). [1H]-NMR(CDCl3) consistent with structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723490 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-554bd9dd465641989667d60605d8d5a8 |
| 출처 메모 | uspto-grants-1998_03 |