Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-1,2,4-Triazole → 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 반응물 | 1,3-Dichloroacetone | HCID 10793 | — |
| 생성물 | 1,3-Bis(1H-1,2,4-triazol-1-yl)-2-propanone | HCID 21982139 | — |
반응 단계
According to the Spanish Patent Number ES 549 020 A1 1 mole of 1,3-dichloroacetone is reacted with 2 mole of 1,2,4-triazole, then the 1,3-bis(1,2,4-triazole-1-yl)-propan-2-on obtained with low yield is reacted with 2,4-difluorophenylmagnesium bromide to give fluconazole. The yield is about 45% calculated on the Grignard reagent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094904B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-c6da0580259c4980b9f5ec2af98dfe19 |
| 출처 메모 | uspto-grants-2006_08 |