참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | 2-Pyrrolidone | HCID 12025 | — |
| 반응물 | 2-Pyrrolidinone, 1-(hydroxymethyl)- | HCID 84911 | — |
| 반응물 | 2-Pyrrolidinone, 1-(chloromethyl)- | HCID 2770497 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(Methoxymethyl)-2-pyrrolidinone | HCID 13624830 | 64% |
반응 단계
N-hydroxymethyl pyrrolidinone is a compound known in the art as an intermediate in the preparation of dyestuffs. As taught in U.S. Pat. No. 3,073,843, this material is prepared by the reaction of pyrrolidinone and formaldehyde or a precursor of formaldehyde. This patent does not suggest the formation of derivatives of this compound however. In addition, Chemical Abstracts, Volume 55, page 27267H (1961) discloses the reaction of N-chloromethyl-2-pyrrolidinone with a mixture of sodium methylate and methanol to yield 64% of N-methoxymethyl-2-pyrrolidinone. Also, Chemical Abstracts, Volume 54, page 1286f (1960) teaches that N-chloromethyl-2-pyrrolidinone can be prepared in 87% yield by treatment of the methylol derivative with SOCl2 in benzene solvent at 8°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US03956313 |
|---|
| 출처 데이터셋 | uspto-grants-1976_05 |
|---|
| ORD ID | ord-111e7a6cc2cf4bf6b7b416acecfbb6b7 |
|---|
| 출처 메모 | uspto-grants-1976_05 |
|---|
