Potassium Cyanide → HCID 21539321, 화합물

HRID 1076228노트

반응식

HRID 1076228 반응식
[CH2:1]1[C:6]2([C:15](=[S:16])[NH:14][C:8]3([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]3)[NH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:17]1([CH3:26])[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[O:25])=[CH:19][CH:18]=1.[C-]#N.[K+].N12CCN(CC1)CC2>C1C=CC=CC=1>[C:17]1([CH3:26])[CH:22]=[CH:21][C:20]([NH:23][C:24]([N:14]2[C:15](=[S:16])[C:6]3([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5]3)[NH:7][C:8]32[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]3)=[O:25])=[CH:19][CH:18]=1

참가 물질

6

반응물 4

HCID 9032Potassium CyanideHCID 9237DabcoHCID 693254-Methylphenyl isocyanateHCID 853997NSC515893

생성물 1

HCID 21539321HCID 21539321, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

4.8 Parts of 7,14-diazadispiro[5.1.5.2]pentadecane-15-thione, 2.92 parts of p-tolyl isocyanate, 0.2 parts of potassium cyanide and a trace of 1,4-diazabicyclo[2.2.2]octane in 100 parts of dry benzene were heated at reflux for 24 hours. The solvent was then evaporated off in vacuo and the residue treated with excess water and allowed to stand for 24 hours. The solution was extracted with chloroform and the axtracts dried and evaporated in vacuo. The residue was crystallised from ethanol to yield 5.4 parts of 14-p-tolylcarbamoyl-7,14-diazadispiro[5.1.5.2]pentadecane-15-thione as a colourless solid of melting point 127° to 129°C. This material gave the following elemental analysis by weight:

후처리

  1. temperatureat reflux for 24 hours
  2. customThe solvent was then evaporated off in vacuo
  3. additionthe residue treated with excess water
  4. extractionThe solution was extracted with chloroform
  5. customthe axtracts dried
  6. customevaporated in vacuo
  7. customThe residue was crystallised from ethanol

출처 및 근거

ORD 기록
ord-01e1def291bc435ea14a4c7daabde2c9
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03956310

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