Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Diiodosalicylic acid → Rafoxanide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Diiodosalicylic acid | HCID 8631 | — |
| 반응물 | Phosphorus trichloride | HCID 24387 | — |
| 반응물 | 4-Amino-2,4'-dichlorobiphenyl ether | HCID 68128298 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | Rafoxanide | HCID 31475 | — |
반응 단계
A mixture of 31.0 g. of 4-amino-2,4'-dichlorobiphenyl ether, 47.4 g. of 3,5-diiodo salicylic acid, and 4.3 ml. of phosphorus trichloride in 235 ml. of chlorobenzene is refluxed for 3 hours. The hot solution is decanted from some insoluble residue and the crude product settles out of solution upon cooling to room temperature. Upon recrystallization from benzene, 27.8 g. of 3,5-diiodo-3'-chloro-4'-(p-chlorophenoxy)-salicylanilide, m.p. 168°-170°C. is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03956488 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-11d59ee90d08415d8557772cd75a0a21 |
| 출처 메모 | uspto-grants-1976_05 |