Ethanol → 5-Benzyl-3-(chloromethyl)-1,2,4-oxadiazole

HRID 1076352노트

반응식

HRID 1076352 반응식
[Cl:1][CH2:2][C:3](=[N:5][OH:6])[NH2:4].Cl.[C:8]1(N=CC(OCC)=O)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH2:21](O)[CH3:22]>>[Cl:1][CH2:2][C:3]1[N:4]=[C:21]([CH2:22][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[O:6][N:5]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 41122522-chloro-N'-hydroxyethanimidamideHCID 21540475Ethyl phenyliminoacetate hydrochloride

생성물 1

HCID 120442135-Benzyl-3-(chloromethyl)-1,2,4-oxadiazole

실험 절차

A mixture of chloroacetamide oxime, 11.0 g. (0.10 mole), and ethyl phenyliminoacetate hydrochloride, 22 g. (0.11 mole), in 80 ml. of absolute ethanol is refluxed for one hour. After cooling, the ammonium chloride which precipitates is filtered off and the alcohol is removed in vacuo. Upon steam distillation of the residue, 7.0 gm. of 3-chloromethyl-5-benzyl-1,2,4-oxadiazole is obtained, n20 1.5386.

후처리

  1. temperatureAfter cooling
  2. customthe ammonium chloride which precipitates
  3. filtrationis filtered off
  4. customthe alcohol is removed in vacuo
  5. distillationUpon steam distillation of the residue, 7.0 gm

출처 및 근거

ORD 기록
ord-c563bab3674c40f2bb308f1a8f37b253
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03956498

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