Morpholine → 4-Quinazolinamine, 2-(4-morpholinyl)-
반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[N:17]=[C:16]([NH2:18])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1>O1CCCC1>[O:4]1[CH2:5][CH2:6][N:1]([C:8]2[N:17]=[C:16]([NH2:18])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH2:2][CH2:3]1참가 물질
4
실험 절차
A solution of 7 g of morpholine in 25 ml of tetrahydrofuran was added dropwise to a solution of 7.2 g of 2-chloro-4-aminoquinazoline in 75 ml of tetrahydrofuran. After the addition was completed, the mixture was heated at reflux overnight. The reaction mixture was evaporated to dryness and the residue was recrystallized twice from ethanol to give 5 g of 2-morpholino-4-aminoquinazoline; m.p. 216°-219°. The following analytical data were obtained.
후처리
- additionAfter the addition
- temperaturethe mixture was heated
- temperatureat reflux overnight
- customThe reaction mixture was evaporated to dryness
- customthe residue was recrystallized twice from ethanol
출처 및 근거
- ORD 기록
- ord-a14c624a0d8449e580f19af0ed656ba0
- 출처 데이터셋
- uspto-grants-1976_05
- 특허 번호
- US03956495
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