Phenazepam → HCID 136353534, 화합물

HRID 1076393노트

반응식

HRID 1076393 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[C:6]=2[CH:20]=1.[O:21]1[CH2:26][CH2:25][N:24]([CH:27](OCC)OCC)[CH2:23][CH2:22]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[C:9](=[CH:27][N:24]3[CH2:25][CH2:26][O:21][CH2:22][CH2:23]3)[N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])[C:6]=2[CH:20]=1

참가 물질

3

반응물 2

HCID 40113PhenazepamHCID 133024324-(Diethoxymethyl)morpholine

생성물 1

HCID 136353534HCID 136353534, 화합물

반응 조건

온도
140 °C

실험 절차

A mixture consisting of 5 gm of 7-bromo-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one and 17 ml of morpholino-diethoxy-methane was heated for 90 minutes at 140°C, while stirring, and the reaction mixture was then allowed to cool. The cool product was admixed with 150 ml of petroleum ether (b.p. 60°-80°C), the mixture was briefly brought to the boiling point, allowed to cool, and the crystalline substance which had separated out was collected by vacuum filtration and recrystallized from isopropanol, yielding the compound named in the heading, which decomposed slowly between 156° and 185°C.

후처리

  1. temperatureto cool
  2. temperatureto cool
  3. customthe crystalline substance which had separated out
  4. filtrationwas collected by vacuum filtration
  5. customrecrystallized from isopropanol
  6. customyielding the compound
  7. customdecomposed slowly between 156° and 185°C.

출처 및 근거

ORD 기록
ord-de986cc630c8429b80b20b08e0474375
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03956492

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