Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tributylamine → 1-(3,3-Diphenylpropyl)-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tributylamine | HCID 7622 | — |
| 반응물 | Toluene, alpha-chloro-2,3,4-trimethoxy- | HCID 97491 | — |
| 반응물 | N-3,3-Diphenylpropylpiperazine | HCID 10356330 | — |
| 용매 | Ethylene glycol diethyl ether | HCID 12375 | — |
| 생성물 | 1-(3,3-Diphenylpropyl)-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine | HCID 21537809 | 91.2% |
반응 단계
N-3,3-Diphenylpropylpiperazine in the amount of 1.4 g (0.005 mole), 1.1 g (0.005 mole) of 2,3,4-trimethoxybenzyl chloride, and 0.93 g (0.005 mole) of tributylamine were dissolved in 10 ml of ethylene glycol diethyl ether, and the resulting solution was heated at the refluxing temperature for 2.5 hours. The reaction liquid was left to cool, and filtered, and concentration of the filtrate under reduced pressure produced 2.1 g of oily 1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine (91.2% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03957790 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-1a452d457cd349aaa31e2f8de88323f2 |
| 출처 메모 | uspto-grants-1976_05 |